Engineering Affinity Windows to Balance Potency, Safety & Durability in Bispecifics & T-Cell Engagers
- Designing optimal affinity windows across tumor and CD3 arms to drive effective synapse formation, while avoiding excessive T-cell activation and offtumor toxicity
- Understanding how affinity tuning influences serial killing, T-cell exhaustion, and durability of the response, particularly in solid tumor settings
- Applying affinity engineering strategies early in bispecific and T-cell engager design to improve clinical predictability and reduce downstream safety and development risk