Exploring How Cis-Acting PD-1 Bispecific Antibodies Enable Tunable Checkpoint Modulation Through Immune Synapse Sequestration or Recruitment
- Outline the cis-acting PD-1 bispecific framework that enables programmable checkpoint modulation by controlling PD-1 spatial positioning at the immune synapse through defined molecular geometry
- Exploring how this design strategy supports both antagonist and agonist outcomes, linking synapse exclusion or recruitment of PD-1 to distinct signaling states and T-cell functional programs without Fc receptor dependence
- Discussing how this approach establishes a unified path from molecular design and epitope selection to disease-relevant immune modulation across oncology and autoimmune models