Saso Cemerski
Executive Director, Head of Immune Engagers AstraZeneca
Dr. Saso Cemerski is Executive Director and Head of Immune Engagers at AstraZeneca. With a background spanning immunology, oncology, and biologics engineering, he previously held scientific leadership roles at Cue Biopharma, Merck Research Labs, and Bristol‑Myers Squibb. Dr. Cemerski completed his PhD in Immunology at Université Paul Sabatier and conducted postdoctoral research at Washington University School of Medicine.
Seminars
Wednesday 10th June 2026
Engineering Affinity Windows to Balance Potency, Safety & Durability in Bispecifics & T-Cell Engagers
11:30 am
- Designing optimal affinity windows across tumor and CD3 arms to drive effective synapse formation, while avoiding excessive T-cell activation and offtumor toxicity
- Understanding how affinity tuning influences serial killing, T-cell exhaustion, and durability of the response, particularly in solid tumor settings
- Applying affinity engineering strategies early in bispecific and T-cell engager design to improve clinical predictability and reduce downstream safety and development risk
