Reshaping the Patient T-Cell Landscape: Overcoming T-Cell Engager Limitations Through Cytokine Combination Strategies

• Examining key limitations of current T-cell engager therapies, including T-cell exhaustion, suboptimal activation, and durability challenges in solid tumors, and where rational combination strategies are emerging as a solution
• Discussing the scientific rationale for combining T-cell engagers with immunocytokines to reshape the tumor microenvironment and enhance T-cell expansion, activation, and persistence
• Exploring translational and clinical development considerations for advancing cytokine + TCE combinations into phase 2 studies, including biomarker strategy and anticipated indicators of synergy

Speakers:

Nari Yun

Chief Development Officer

GI Innovation